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drug resistant cell line mes sa dx5  (ATCC)


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    ATCC drug resistant cell line mes sa dx5
    Drug Resistant Cell Line Mes Sa Dx5, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 106 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/drug+resistant+cell+line+mes+sa+dx5/MES-SA/pm25590413-157-7-11
    Average 95 stars, based on 106 article reviews
    drug resistant cell line mes sa dx5 - by Bioz Stars, 2026-10
    95/100 stars

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    Cell Culture:

    Article Title: Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line.
    Article Snippet: Objective.. Chemotherapy is highly effective in treating a number of gynecologic malignancies; however, its effectiveness diminishes with repeated exposures due to the emergence of multi-drug resistance (MDR).. The aim of this study was to establish a permanent MDR gene knockdown model via infection with the siRNA-hairpin expression vector.

    Article Title: Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells.
    Article Snippet: .. Materials and methods Cell culture The multiple drug-resistant cell line MES-SA/Dx5 (ATCC, CRL-1977) was established from the human sarcoma cell line MES-SA (ATCC, CRL-1976) in the presence of increasing doxorubicin concentrations. .. 23 All cell lines were continuously maintained in McCoy’s 5A medium (Invitrogen, 16600) supplemented with 10% fetal bovine serum (Invitrogen, 10099) and 1% Antimycotics (Invitrogen, 15240) under 95% air and 5% CO2 at 37 °C.

    Article Title: FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells.
    Article Snippet: Multidrug-resistant (MDR) cancer is a major clinical problem in chemotherapy of cancer patients.. We have noted inappropriate PKC hypomethylation and overexpression of genes in the PKC /AP-1 pathway in the human uterus sarcoma drug-resistant cell line, MES-SA/Dx5 cells, which also overexpress p-glycoprotein (ABCB1).. Recent studies have indicated that FZD1 is overexpressed in both multidrugresistant cancer cell lines and in clinical tumor samples.



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